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 Clenbuterol - is my body becoming accustom to it?


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spenone

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Clenbuterol - is my body becoming accustom to it? 07 February 2012 12:02 (permalink)
Hi all.
Have been running clen on and off for past year now.
 
Last week I started again after about a 3 week break.
 
Started at 40mcg
60mcg
80mcg
100mcg
120mcg
140mcg for 3 days now.
 
First day - no shakes no problems.
Day 2 - 3 - great side effects really working away.
Now I have stabilized at 140mcg/day I have no sides and **** all effect.
 
Are my receptors blocking the affect of this drug? Should I stop it for a few months? Not that I want to. As I usually take to clen excellently. Or what do you think could be the problem.
Clen is the same as I have always used, very reliable and trust worthy source and legitimate product.
 
Any ideas would be great.
 
#1
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    W1LL

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    Re:Clenbuterol - is my body becoming accustom to it? 07 February 2012 14:03 (permalink)
    I would say your receptors wil be de-sensatized after sucha long time on.
     
    There is something you can take to clean the receptors but I can't remember what it's called. Sorry.
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    #2
      stone14

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      Re:Clenbuterol - is my body becoming accustom to it? 07 February 2012 14:43 (permalink)
      it begins with k keto-sumit i think, you can run clen continuous on it, cant rember its name either lol will be in this section some were tho
      i believe with a healthy active lifestyle and some good knowledge and aas/peps use etc that you can live a longer stronger better life.

      main interests: physique conditioning, bbj, muay thai.
       
      #3
        stone14

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        Re:Clenbuterol - is my body becoming accustom to it? 07 February 2012 14:44 (permalink)
        i believe with a healthy active lifestyle and some good knowledge and aas/peps use etc that you can live a longer stronger better life.

        main interests: physique conditioning, bbj, muay thai.
         
        #4
          thoon

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          Re:Clenbuterol - is my body becoming accustom to it? 07 February 2012 19:47 (permalink)
          I see a lot of newbie people trying to find good info on this so I thought it would be best to put it all in one place. I patched this from a wide range of sources as well as my own experience (also thanks to FONZ). This truly is a wonderdrug for BB. 

          What Is It?
          Ketotifen is very safe antihistamine used extensively in Europe to treat bronchial asthma and allergies. It is also being studied as a treatment for colitis. When used for asthma, weight gain and an increase in appetite are among the most frequent side effects. Ketotifen also protects the cells in the stomach, small intestine and perhaps the rest of the gut from a number of toxins. A number of case studies suggest that it may be helpful treating skin problems such as acne. Ketotifen also reduces edema (swelling and puffiness caused by water retention) around sores. 
          Ketotifen Studies German researchers have published data showing that ketotifen lowers tnf-alpha in the test tube. One study used ketotifen in combination with oxymethadone, a steroid like Megace that helps people gain weight, so it is hard to gauge what effect ketotifen had (the study notes a 14% reduction in TNF-alpha levels and weight gains of 11-12 pounds in less than four weeks). A larger placebo controlled study of this combination is underway. The other study used ketotifen by itself in eight patients with elevated TNF-alpha, (but no wasting). Taking ketotifen for 12 weeks, these patients gained an average of six pounds, had increases in their body cell mass and reductions in their TNF-alpha levels. 
          Side Effects and Toxicity Ketotifen is virtually non-toxic (although it is not advised for patients with epilepsy). People who took twenty times the recommended dose (in suicide attempts) suffered no serious consequences (other than embarrassment). Its primary side effects seem to be temporary drowsiness, dry mouth,(and other mucuos membranes) appetite stimulation and weight gain. 
          Dosing and side effects No studies have been done to find the most effective dose but the German researchers used 4 mg ED. Dan Duchaine (who discovered ketos use for BB) suggested 10mg ED but in my experience this much is not needed and makes u far too sleepy. I find that 3-4mg ED seems ideal. However, much higher doses have been shown to be quite safe with no adverse affects other than increased drowsiness and appetite – it will make u hungry for solid foods. You can take it divided in the day or all at once. 
          Ketotifen and Clen Clenbuterol is a beta 2 agonist which has a limited anabolic effect during its first few days of use and afterward is normally used to fight fat. At higher doses, however, it can be catabolic to muscle and it must be cycled on a 2 week on, 2 week of basis or the beta 2 receptors that clen binds to become saturated and down regulate. 
          Ketotifen’s magic is that it upregulates the beta-receptors including the beta 2s that clen uses. As long as you are taking ketotifen, it will continue to clean these receptors, never allowing them to downregulate – even while on a heavy clen cycle. That means you can continue to take clen indefinitely without having to cycle off to regenerate the receptors. 2-3mg ED can upregulate even severely shut down receptors within a week. 
          It also means that you don’t need as much clen to get the same benefits. It seems u can take about 30-40% less clen and it be equally effective. FONZ posted that it also increases the number of receptor sites on the surface of the cell, allowing more clen to attach and perhaps this is the reason for the increased efficacy. Ketotifen also seems to lessen the sides of clen including the jitters. 
          Ketotifen and ECA Perhaps an even better use for ketotifen is taking it with the ECA stack. While the thermogenic effect of ephedrine is not as potent as clen because it doesn't have a high receptor affinity, and it is not limited to beta-2 receptors. In fact it seems to have a good effect on beta 3 receptors as well, which act as a type of thermogenic messenger and over half of ephedrine effect is from beta-3 stimulation. Clen has almost no effect on beta 3 however. So by keeping the beta 2 receptors up, ketotifen can allow the benefits of continuous beta 2 and beta 3 stimulation from ephedrine. 
          "Ephedrine is believed to have some direct effect on both alpha adrenoceptors and beta adrenoceptors, but AT THERAPEUTIC DOSES, ephedrine exerts its thermogenic effect almost entirely via stimulating noradrenaline release from the sympathetic nerve terminals [endings] . . . at least 40% of the [thermogenic] response is mediated by an atypical receptor, which is presumed to be the beta 3-adrenoceptor." 
          from Liu YL, Toubro S, Astrup A, Stock MJ Contribution of beta 3-adrenoceptor activation to ephedrine-induced thermogenesis in humans Int J Obes Relat Disord. Sep;19(9). 678-685 
           
          Whether this stuff works or not i don't know but worth a try 
           
          #5
            Sharpiedj

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            Re:Clenbuterol - is my body becoming accustom to it? 11 February 2012 09:11 (permalink)
            thoon on it again
            The last three or four reps is what makes the muscle grow. This area of pain divides the champion from someone else who is not a champion.
             
            #6
              Oaken

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              Re:Clenbuterol - is my body becoming accustom to it? 11 February 2012 09:35 (permalink)
              Thoon, it is nice you take the time, and in this case you can't paste the link as its a sourcing website and MT stars out some of the link. But it would be rather prudent if you would mention that what you paste is in fact a complete copy and paste and not your own work. IMO thats the way to do it.
               
               
              <message edited by Oaken on 11 February 2012 13:14>



               
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