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Re:HST on cycle?
27 February 2010 12:34
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and some more Cycling lengths Blade: The short cycle concept was popularized by Bill Roberts, but I heard of it many years ago - even the late Duchaine talked warmly about it. There is only one study that I know of, and that one used Testosterone Propionate for 2 weeks. The reasoning is that using short-acting esters (propionate, acetate + orals) and ending the cycle before the 14 day point will restore endogenous T faster than a longer cycle. Whether it is 14 days or longer is not proven yet, but anecdotal evidence points to 14 days being pretty close to it, and going past this point will prolong recovery. This translates into it being more reasonable to do a cycle of sufficient duration to actually add some muscle mass, since cycles of 3-7 weeks requires the duration of recovery sometimes equalling the length of time, but occasionally just as long as cycles lasting 8-12 weeks. 8-10 weeks is close to optimal, and 12 weeks is pushing it in terms of increased risk of HPTA recovery problems - or moreso the length of recovery will dictate post-cycle losses which in this case would be excessively lengthy. I've personally used 2on/4off cycles with great success in many of my clients, and also received positive feedback from the multitude of people who have tried it after being inspired from my online articles. 2 weeks off might not allow full HPTA recovery in individual cases, but should also be OK provided proper auxillary supplements. 4-5 2on/2off cycles can be strung together before taking 4 or more weeks off, and then HCG might be needed in case of testicular atrophy. One isolated 2 week cycle is ineffective, since the body needs some time to adapt to levels of hypertrophy beyond the genetic potential (or more specifically satellite cell activity and hyperplasia). For most people wanting to achieve as much muscle mass as possible within a short timeframe, I usually recommend 10 week cycles. It all depends on your goals. Bryan: The problem with a 4-5wk on/3wk off cycle is that you can't gain enough mass to carry you through the recovery period, (assuming you don't use clomid and hCG). In other words, 2on/4off works because your natural test recovers so quickly that your baseline levels are able to support the new mass you've gained (this does not apply for a bodybuilder who is already sporting a lot of extra muscle) until the next cycle. With the Borresen cycle you are simply wasting your time during the 3 week period because your levels won't return in that period of time, then for 4-5 weeks you won't be able to build "significant" mass either. Will it work at all? Depends on your history of use and current mass. Now, if using an estrogen antagonist and gonadotropin (e.g. HCG) you can do whatever you like and your baseline test levels will be maintained. Cycle however you want and you will always have a soft landing. This does not mean you will "keep" any amount of mass you gain. Your baseline test will only be able to support a given amount of muscle mass. The amount of mass your natural levels can support will be however big you "stay" once you have been "off" for at least a year or so. This is usually more than you can build naturally simply because of the effects of androgens on satellite cells and fiber number. Fiber number will stay higher even if diameter returns to normal. So, I guess what I'm trying to say, is that if you are going on for longer than 2 weeks, you have to stay on long enough (6-8 weeks) to build more muscle than you will lose when you go off - with low test lasting for at least as long as you were "on". That's at least a general rule of thumb - test levels will stay low for about as long as you were on (without antiestrogens and hCG). If you are bigger than you could have gotten naturally, you will generally lose most of the mass you gained during the cycle. If you are still below your "natural" limit, you may keep a bit more. Using Test does change things, at least until you max out your dose (voluntarily or otherwise) and your growth stops for at least 8 weeks without changing anything. So when you reach a point of stagnation both in dose and weight gain, you are essentially in the same situation as a natural lifter, but at a much elevated body mass. If you are competing at a high level and stay "on" year round, you should do HST as prescribed, SD and all. If however, you are doing cycles on and off. you need to carefully time everything to avoid a crash. One thing to also note, strength seems to increase to dangerous levels when using high dose Test and HST at the same time. It is advised the reps not drop any lower than 8 in such circumstances. Always use your head, not just your ego. More on Prohormones Various prohormones require conversion into other androgens before they are actually anabolic and/or androgenic. In essence, until they pass through a enzymatic conversion, they are inert in the body. 4-androstenediol (4-AD) requires conversion but it also posses some anabolic/androgenic activity before conversion. Yes, it acts as a "class II" androgen, meaning it does not bind strongly to the androgen receptor, nor does it appear to stay bound. In contrast, DHT binds both strongly and does not easily separate from the receptor. Keep in mind however that both androgens act on the exact same receptor. The differences in their effects are caused by the strength and duration of their bond with the receptor. The risks of using any androgen are similar, differing only in their severity. It all depends on the dose. And yes, side effects include alterations in cholesterol ratios, reduction in testosterone production, hair thinning, oily skin, alterations in libido, etc. The positive effects are increases muscle mass, increased bone mass, decreased fat mass, increased energy levels, increased libido, increased mental focus, and elevated mood, and a few others. However, it is important to remember that all of these effects are dependant on how androgens are used. There are many thousands of men on testosterone replacement who experience nothing but positive effects. When someone in the supplement industry talks about prohormones and side effects in the same sentence they are talking about either of 2 things, the conversion into estrogen, and the potency of the androgen itself. If an androgen doesn’t “aromatise” it doesn’t convert into estrogen, therefore it won’t produce any estrogen-related side effect like gyno. Keep in mind that estrogen levels also regulate testosterone production, the more estrogen you have floating around the less testosterone will be produced in the testes. The potency of an androgen is self explanatory and relates to side effects such as hair thinning as well as suppression of test production. You are fooling yourself is you think that using a prohormone is “not” androgen use. Of course it is. In a general sense, it’s no different than using testosterone from a syringe. But you have to make up your mind about whether you feel male hormones are evil or good. If you feel they are evil, don’t use them and pray for the day when your own natural levels diminish. If you feel they are good, learn everything you can about them and the body’s endocrine system, and them use them as a tool to accomplish your physique augmentation goals. The notion that knowledge and lifting technique can “replace” androgen use and produce comparable gains in muscle mass is false. Once a person has maxed out his body’s ability to support more muscle tissue, he will not grow any larger until his hormones increase as well. Using androgens before your LBM is naturally maxed out will only get you their faster. Not only that, but a natural lifters physique will almost always show different proportions than an individual using androgens, even if their overall body mass is the same. There is only one receptor for androgens. Thus, testosterone, prohormones, and synthetic anabolic steroids all work the same way. They all cause anabolism through the androgen receptor. Most do this through nuclear receptors, others also interact with androgen receptors at the cell membrane. So, anything we say about prohormones, also applies to testosterone and anabolic steroids. The only difference (I’m generalizing a little bit) is seen by different amounts used and for different periods of time. The effects of Androgens are dose dependant. All androgens cause muscle growth by a similar mechanism(s). · Enhanced growth factor activity (e.g. GH, IGF-1, etc.) · Enhanced activation of myogenic stem cells (i.e. satellite cells) · Enhanced myonuclear number (to maintain nuclear to sarcoplasmic ratio) · Enhanced protein synthesis · Enhanced amino acid recycling within muscle cells · New myofiber formation All of these things lead to bigger muscles, whether you train or not. Add to these effects, Hypertrophy-Specific Training and Hypertrophy-Specific Nutrition and you see dramatic increases in muscle mass. Now when a person quits using prohormones/steroids, they have a greater number of myonuclei than they did before and additional new muscle fibers. This allows them to maintain a greater amount of muscle mass than they could have naturally. This “recently-natural” look is what you see in a lot of magazines today. As long as you can maintain the new myonuclei, and new muscle fibers, you will store up muscle memory and a greater potential for later drug-free regrowth. A few helpful pointers from Bryan Focusing on volume would be better than on frequency. Androgens don't accelerate the rate at which a cell repairs itself or builds proteins. Androgens enhance the magnitude of the response....make sense? I think you will experience better results doing more sets per workout, rather than doing more workouts, as long as you are using a ~48 hour frequency. Take your days off to focus on getting an appropriate amount of protein and good carbs. The exception: When the weight loads get light enough (especially 1st week of 15) doing higher frequency is recommended while leaving the volume (~2 sets/exercise) pretty much the same. This is because there is less damage/inflammation caused by the lighter weights. 15s cause more of an "acute" anabolic effect (amino acid uptake, PGs, ribosomes, etc) without activating significant satellite cell activity. Using an antiestrogen can increase testosterone levels, but they will need to increase considerably before you begin to see a significant anabolic effect. For example, if you are taking straight testosterone, you probably won't see a whole lot of extra growth until you reach 400-600mgs per week. below that you do get some effects but it is mostly mood, and perhaps exercise tolerance. So in short, taking an antiestrogen probably won't be terribly "anabolic" at the tissue level. It may however help you retain some mass you gained while using androgens. - Bryan
<message edited by buzzer on 27 February 2010 12:37>
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