Purus Labs' Organ Shield for SD cycle... opinions please!

Im thinking of running Organ Shield at 2 caps/day. here's the break down

Serving Size: 2 caps
Servings per Container: 30


Amount Per Serving % Daily Value

Milk Thistle (standarized for 80% silymarin) 300mg **
Beta-Sitosterol (Pygeum africnum) 250mg **
Saw Palmetto (Serenoa Repens) (berries) 200mg **
N-Acetyl-L-Cysteine (NAC) 250mg **
Alpha Lipoic Acid (ALA) 150mg **
Quercitin Dihydrate 150mg **
Coenzyme Q-10 (CoQ10) (trans-isomer) 100mg **

This is for my SD cycle. (looking at this product after the rumours of RYR not containing the active ingredient)

What do you guys think?

Im using this for mine, starting it in two weeks, cant wait. Will try keep a small log

Looks nothing special

looks under dosed on a few ingredients to me from what ppl usually recommend.

I'd used 2000-3000mg of Milk Thistle (standarized for 80% silymarin) and 1200-1500mg N-Acetyl-L-Cysteine (NAC) a day divided in to 2-3 doses.

have a look at 'cycle insurance' it might have a bit more of what ur looking for but be aware it taste awfull.

Anabolic Innovations Cycle Support

Purus are a stand up company, they don't just throw in ingredients at doses which are 'supposed' to be right according to common conseus (which as we all well know in the fitness world is so often wrong), they have solid research backing up the ingredients & the doses they are included at.

I would be more than happy to recommend Organ Shield as being a good support option to anyone and it is now the only support supp I use personally anyway.

lol @ the product name. What will they come up with next!

IronLabs

they have solid research backing up the ingredients & the doses they are included at.

Interesting. Could you direct us to the independant, controlled study data which demonstrates efficacy of the actual product or individual components using 17-aa steroid using subjects?

PartyBoy
Interesting. Could you direct us to the independant, controlled study data which demonstrates efficacy of the actual product or individual components using 17-aa steroid using subjects?

Research behind the product's ingredient profile & dosage.


1.    Randi L. Edwards, Tiffany Lyon, Sheldon E. Litwin, Alexander Rabovsky, J. David Symons, Thunder Jalili. Quercetin Reduces Blood Pressure in Hypertensive Subjects. J. Nutr. 137:2405-2411, November 2007

2.    Lin LY, Peng CC, Yang YL, Peng RY. Optimization of bioactive compounds in buckwheat sprouts and their effect on blood cholesterol in hamsters. J Agric Food Chem. 2008 Feb 27;56(4):1216-23. Epub 2008 Jan 24.

3.    Juźwiak S, Wójcicki J, Mokrzycki K, Marchlewicz M, Białecka M, Wenda-Rózewicka L, Gawrońska-Szklarz B, Droździk M. Effect of Quercetin on experimental hyperlipidemia and atherosclerosis in rabbits. Pharmacol Rep. 2005 Sep-Oct;57(5):604-9.

4.    Zern TL, Wood RJ, Greene C, West KL, Liu Y, Aggarwal D, Shachter NS, Fernandez ML. Grape polyphenols exert a cardioprotective effect in pre and postmenopausal women by lowering plasma lipids and reducing oxidative stress. J Nutr. 2005 Aug;135(8):1911-7.

5.    U. Cornelli, R. Terranova, S. Luca, M. Cornelli, and A. Alberti  Bioavailability and Antioxidant Activity of Some Food Supplements in Men and Women Using the D-Roms Test as a Marker of Oxidative Stress J. Nutr. 2001 131: 3208-3211.

6.    Singh RB, Niaz MA, Rastogi V, Rastogi SS. Coenzyme Q-10 in cardiovascular disease. J Assoc Physicians India. 1998 Mar;46(3):299-306.

7.    Sinatra ST, DeMarco J. Free radicals, oxidative stress, oxidized low density lipoprotein (LDL), and the heart: antioxidants and other strategies to limit cardiovascular damage. Conn Med. 1995 Oct;59(10):579-88.

8.    Asghar Z, Masood Z. Evaluation of antioxidant properties of silymarin and its potential to inhibit peroxyl radicals in vitro. Pak J Pharm Sci. 2008 Jul;21(3):249-54.

9.    Tamayo C, Diamond S. Review of clinical trials evaluating safety and efficacy of milk thistle. Integr Cancer Ther. 2007 Jun;6(2):146-57.

10.    Guler G, Turkozer Z, Tomruk A, Seyhan N. The protective effects of N-acetyl-L-cysteine epigallocatechin-3-galate on electric field-induced hepatic oxidative stress. Int J Radiat Biol. 2008 Aug;84(8):669-80

11.    Mansour HH, Hafez HF, Fahmy NM, Hanafi N. Protective effect of N-acetylcysteine against radiation induced DNA damage and hepatic toxicity in rats. Biochem Pharmacol. 2008 Feb 1;75(3):773-80. Epub 2007 Sep 25.

12.    Kortsalioudaki C, Taylor RM, Cheeseman P, Bansal S, Mieli-Vergani G, Dhawan A. Safety and efficacy of N-acetylcysteine in children with non-acetaminophen-induced acute liver failure. Liver Transpl. 2008 Jan;14(1):25-30.

13.    Habib FK, Ross M, Ho CK, Lyons V, Chapman K. Serenoa repens (Permixon) inhibits the 5alpha-reductase activity of human prostate cancer cell lines without interfering with PSA expression. Int J Cancer. 2005 Mar 20;114(2):190-4.

14.    Prager N, Bickett K, French N, Marcovici G. A randomized, double-blind placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenic alopecia. J Altern Complement Med. 2002 Apr;8(2):143-52.

15.    J. M. R. Beveridge, H. L. Haust, and W. Ford Connell Magnitude of the Hypocholesterolemic Effect of Dietary Sitosterol in Man J. Nutr. 1964 83: 119-122.

16.    J. M. R. Beveridge, H. L. Haust, and W. Ford Connell Magnitude of the Hypocholesterolemic Effect of Dietary Sitosterol in Man J. Nutr. 1964 83: 119-122.

17.    D. W. Peterson, E. A. Shneour, N. F. Peek, and H. W. Gaffey Dietary Constituents Affecting Plasma and Liver Cholesterol in Cholesterol-Fed Chicks J. Nutr. 1953 50: 191-201.

18.    Stephanie D. Wollin and Peter J. H. Jones  -Lipoic Acid and Cardiovascular Disease J. Nutr. 2003 133: 3327-3330.

19.    Ghibu S, Richard C, Delemasure S, Vergely C, Mogosan C, Muresan A. An endogenous dithiol with antioxidant properties: alpha-lipoic acid, potential uses in cardiovascular diseases. Ann Cardiol Angeiol (Paris). 2008 Jun;57(3):161-5. Epub 2008 Jun 4.

20.    Lal A, Atamna W, Killilea DW, Suh JH, Ames BN. Lipoic acid and acetyl-carnitine reverse iron-induced oxidative stress in human fibroblasts. Redox Rep. 2008;13(1):2-10.

21.    Park KG, Min AK, Koh EH, Kim HS, Kim MO, Park HS, Kim YD, Yoon TS, Jang BK, Hwang JS, Kim JB, Choi HS, Park JY, Lee IK, Lee KU. Alpha-lipoic acid decreases hepatic lipogenesis through adenosine monophosphate-activated protein kinase (AMPK)-dependent and AMPK-independent pathways. Hepatology. 2008 Nov;48(5):1477-86.

22.    Jariwalla RJ, Lalezari J, Cenko D, Mansour SE, Kumar A, Gangapurkar B, Nakamura D. Restoration of blood total glutathione status and lymphocyte function following alpha-lipoic acid supplementation in patients with HIV infection. J Altern Complement Med. 2008 Mar;14(2):139-46.

Yes I'm aware of the studies cited by the manufacturers, which is why I specifically asked for:

"controlled study data which demonstrates efficacy of the actual product or individual components using using 17-aa steroid using subjects"


After all, this is exactly the target market for the product, so efficacy should be demonstrated within this demographic
using 17-aa steroid using subjects

partyboy, which supplement(s) would you use to help most on cycle?

For alkylated orals just get some milk thistle or Liv52. Having said that, it's my belief that even this is not particularly essential given the blood works I've seen including my own when using modest doses and durations.

Can't hurt though and gives most people more peace of mind if they run a liver supp.

1000mg Milk Thistle (standarized for 80% silymarin) and 1200mg N-Acetyl-L-Cysteine divided in to two to three doses a day seems to be the way to go. Personally i used 2000-3000mg of milk thistle powder with around 1200mg NAC.

NAC does seem a popular choice

however, the milkt thistle lessening the PH effect is worrying

This is in the steroid forum:

http://www.muscletalk.c...lable-here-m3733718.aspx

thanks partyboy, so that would be your ideal choice for liver support

and it apparently helps in terms of cholesterol too

it just seems too good to be true!

but it would seem cycle support covers more bases though....

The question you need to ask yourself is this:

Do you believe that your organs are at risk and need 'protecting' from the effects of a modest cycle?


I know what my answer is :-)

PartyBoy


The question you need to ask yourself is this:

Do you believe that your organs are at risk and need 'protecting' from the effects of a modest cycle?


I know what my answer is :-)

the thing is, it will be SD and i know how potent/harsh that can be. i want to be as 'protected' as i can be without actually not taking it if you get me.