Regarding quality of evidence on the internet:-
At the bottom of the pile is inexpert opinion. Basically, anyone can say anything but that doesn't make it true! This includes anything that I say, which is why I try to back up what I say with evidence from higher up the pile.
Next up is anecdotal data/testimonials.
Further up the pile is expert opinion. Even "experts" with lots of letters after their name have personal bias, hence the controversy over MMR, HIV/AIDS, lipid hypothesis etc.
Further up the pile is epidemiological data. A being associated with B doesn't mean that A causes B, as the association may be due to random chance or due to both being caused by C, D, E.....etc.
Further up the pile is case study data.
Further up the pile is data from small/non-randomised/unblinded trials.
At the top of the pile is data from large, randomised, double-blinded,
placebo-controlled, crossover trials.
However, even at the top of the pile, an outcome can be manipulated by tweaking the methodology (e.g. using pre-trial screening) so if a trial is funded by a large company, the methods used need to be examined. In addition, the abstract can mis-represent the full study.
Oy!
<message edited by Nigeepoo on 14 December 2008 14:49>