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Over-The-Counter Pain Killers Increase Muscle Mass PDF Print E-mail
Written by Federation of American Societies for Experimental Biology
Monday, 07 April 2008

ScienceDaily (Apr. 7, 2008) - Taking daily recommended dosages of ibuprofen and acetaminophen caused a substantially greater increase over placebo in the amount of quadriceps muscle mass and muscle strength gained during three months of regular weight lifting, in a study by physiologists at the Human Performance Laboratory, Ball State University.

Thirty-six men and women, between 60 and 78 years of age (average age 65), were randomly assigned to daily dosages of either ibuprofen (such as that in Advil), acetaminophen (such as that in Tylenol), or a placebo. The dosages were identical to those recommended by the manufacturers and were selected to most closely mimic what chronic users of these medicines were likely to be taking. Neither the volunteers nor the scientists knew who was receiving which treatment until the end of the study.

All subjects participated in three months of weight training, 15-20 minute sessions conducted in the Human Performance Laboratory three times per week. The researchers knew from their own and other studies that training at this intensity and for this time period would significantly increase muscle mass and strength. They expected the placebo group to show such increases, as its members did, but they were surprised to find that the groups using either ibuprofen or acetaminophen did even better.

An earlier study from the laboratory, measuring muscle metabolism (or more precisely, muscle protein synthesis, the mechanism through which new protein is added to muscle), had looked at changes over a 24 hour period. This "acute" study found that both ibuprofen and acetaminophen had a negative impact, by blocking a specific enzyme cyclooxygenase, commonly referred to as COX.

But that study looked at only one day. Over three months, says Dr. Trappe, the chronic consumption of ibuprofen or acetaminophen during resistance training appears to have induced intramuscular changes that enhance the metabolic response to resistance exercise, allowing the body to add substantially more new protein to muscle.

The amount of change was measured in quadricep muscles using Magnetic Resonance Imaging (MRI), the gold standard for determining muscle mass. The researchers now are conducting assays of muscle biopsies taken before and after the three-month period of resistance training, in order to understand the metabolic mechanism of the positive effects of ibuprofen and acetaminophen.

One of the foci of Ball State's Human Performance Laboratory is the adaptation of the elderly to exercise. Another is the loss of muscle mass that takes place when astronauts are exposed to long-term weightlessness. This work has implications for both groups, says Dr. Trappe.

*This presentation was part of the scientific program of the American Physiological Society (APS). In addition to Dr. Carroll and Dr. Trappe, co-authors of the Experimental Biology presentation are Jared Dickinson, Jennifer Lemoine, Jacob Haus, and Eileen Weinheimer, graduate students working with Dr. Trappe, and study physician Dr. Christopher Hollon.

Funding for the research came from the National Institutes of Health and a postdoctoral initiative award from APS.

Adapted from materials provided by Federation of American Societies for Experimental Biology, via EurekAlert!, a service of AAAS.

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ORIGINAL: James

Hi David - good to see you've joined and are posting

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Your comment at the bottom about PGF2a - what do you mean? Is it available as a tonic?

You are referring to prostaglandin F2 alpha, are you? as in the one responsible for labour?

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I'm interested to learn more

The Anabolic Index is HERE!

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ORIGINAL: Tomazi8

ScienceDaily (Apr. 7, 2008) - Taking daily recommended dosages of ibuprofen and acetaminophen caused a substantially greater increase over placebo in the amount of quadriceps muscle mass and muscle strength gained during three months of regular weight lifting, in a study by physiologists at the Human Performance Laboratory, Ball State University.

The Anabolic Index is HERE!

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ORIGINAL: carl19

while were on the topic, do any other drugs effect muscle growth??

im on anti biotics...

The Anabolic Index is HERE!

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ORIGINAL: David Barr

Alcohol (ethanol) is also anti-anabolic. It actually scores a negative 3 on The Anabolic Index.

Fortunately most antibiotics focus on microbial replication, which should have no direct impact on our muscle growth.

This is in contrast to the Anabolic Reference Guide from 1990 that claimed Tetracycline to be an inhibitor of muscle protein synthesis.

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ORIGINAL: carl19

while were on the topic, do any other drugs effect muscle growth??

im on anti biotics...

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ORIGINAL: Nigeepoo

Does adaptation occur in that if substance "X" suppresses bodily process "Y" then, when substance "X" wears off, bodily process "Y" rebounds to a higher than normal level such that the average value of bodily process "Y" remains constant?

EDIT: And vice-versa for substance "X" increasing bodily process "Y".

The Anabolic Index is HERE!

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ORIGINAL: FatboyGinger


Hello David
Welcome to MT

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I've just read that ^^ -been on some sort on Tetracycline for the past couple of years. I've definitely heard ibuprofen blunts protein synthesis.

The Anabolic Index is HERE!

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ORIGINAL: David Barr
That's a great line of thinking Nigeepoo!
A negative feedback system (or something similar) would be yet another type of regulation to dissect. Applying this to PGF2 in this case... I wonder.