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RE: The fatso gene and a fat gene discussion - Apr. 30 2008 12:55:16
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dvdman69
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In my experience of my family and my in-laws, it’s definitely genetic in the majority of cases, although I have one situation which is glandular but the doctors appear not to be concerned they are calling it childhood obesity, I have always looked at the maternal grandfather for the outcome of the male children, and certainly in the cases close to me this has been 100% the case. But with women it appears to be a 50/50 thing, they can go either way, no definite direction.
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RE: The fatso gene and a fat gene discussion - Apr. 30 2008 13:14:14
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Tony Barnes
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Do you have links at all James? Never heard o fit, and can't find squat..!!
Assuming it increases fat deposition, there would surely be an activator/inhibitor system anyway?
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RE: The fatso gene and a fat gene discussion - Apr. 30 2008 13:54:13
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James
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quote:
ORIGINAL: Tony Barnes
Do you have links at all James? Never heard o fit, and can't find squat..!!
Assuming it increases fat deposition, there would surely be an activator/inhibitor system anyway?
quote:
but it's a struggle to find any decent info - a google search revealed nothing!
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RE: The fatso gene and a fat gene discussion - Apr. 30 2008 14:14:32
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daveo
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My unqualified opinion is that 99.9% of people would not be fat if they had a balanced, structured diet and got a bit of excercise.
This fatso gene is just an excuse for people to use.
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RE: The fatso gene and a fat gene discussion - Apr. 30 2008 14:16:32
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James
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quote:
ORIGINAL: daveo
My unqualified opinion is that 99.9% of people would not be fat if they had a balanced, structured diet and got a bit of excercise.
This fatso gene is just an excuse for people to use.
It's not an excuse, it's not even well publicised as yet.
Did you even read my quote above?
quote:
Is the fatso gene the so called 'thrifty genotype', a theory which has been around for decades? Although for sure diet, exercise and lifestyle are primary reasons for obesity, is the fatso gene a 'genetic nudge' in the wrong direction?
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RE: The fatso gene and a fat gene discussion - Apr. 30 2008 14:31:57
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daveo
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Oh absolutely, but i think a lot of people will use it as their excuse whether or not it exists and they have it.
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RE: The fatso gene and a fat gene discussion - Apr. 30 2008 15:07:57
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Tony Barnes
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quote:
ORIGINAL: James
quote:
ORIGINAL: Tony Barnes
Do you have links at all James? Never heard o fit, and can't find squat..!!
Assuming it increases fat deposition, there would surely be an activator/inhibitor system anyway?
quote:
but it's a struggle to find any decent info - a google search revealed nothing!
lol, yes, but you were reading something, wasn't sure if it was a bit of paper or a link...  
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RE: The fatso gene and a fat gene discussion - Apr. 30 2008 15:56:12
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gwilym
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There may not be a fatso gene, but could be a skinny gene. Surely this would be just by genetically having higher thyroid hormone levels, therefore keeping you thin - hence the term hardgainer?
Surely if this is the case there could be the opposite - fatso - also?
I may be over simplifying this somewhat, but it makes a lot of sense.
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RE: The fatso gene and a fat gene discussion - May 1 2008 8:41:30
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James
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quote:
ORIGINAL: Tony Barnes
quote:
ORIGINAL: James
quote:
ORIGINAL: Tony Barnes
Do you have links at all James? Never heard o fit, and can't find squat..!!
Assuming it increases fat deposition, there would surely be an activator/inhibitor system anyway?
quote:
but it's a struggle to find any decent info - a google search revealed nothing!
lol, yes, but you were reading something, wasn't sure if it was a bit of paper or a link...
It was an article in Network Health Dietitians which I get monthly: http://www.dietetics.co.uk/topic.asp?TOPIC_ID=896
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RE: The fatso gene and a fat gene discussion - May 1 2008 8:44:13
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James
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quote:
ORIGINAL: gwilym
There may not be a fatso gene, but could be a skinny gene. Surely this would be just by genetically having higher thyroid hormone levels, therefore keeping you thin - hence the term hardgainer?
Surely if this is the case there could be the opposite - fatso - also?
I may be over simplifying this somewhat, but it makes a lot of sense.
Well, the FTSO gene has been discovered now, so there is no 'may' about it, it exists. There may well be some genes which predispose people to being skinny too. However, as for adiposity, it's likely to be polygenic.
(Polygenic means a large number of genes coding for one trait, and the strength of exression is through the number of genes expressed - eg hair colour)
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RE: The fatso gene and a fat gene discussion - May 1 2008 10:06:45
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Tony Barnes
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Ah, ok.
Keep us posted on anything you find
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RE: The fatso gene and a fat gene discussion - May 1 2008 11:49:40
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Medusa
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quote:
ORIGINAL: James
Well, the FTSO gene has been discovered now, so there is no 'may' about it, it exists. There may well be some genes which predispose people to being skinny too. However, as for adiposity, it's likely to be polygenic.
seems to me that it's always been commonly accepted that some people are naturally skinny whilst other tend to be naturally fatter, but in the past 10 years or less larger numbers of very obese people have emerged (my personal observation)
Also it seems that we always knew that some women switch from slim to fat after having children, does having children cause some permenant change in metabolism? I read recently that the closer to menopause you are when you have children the more likely you are to become predisposed to being fat.
I suppose the treatment of the problem depends on how we categorise it, if genetic then overweight people need gene therapy, if emotional then counselling, ior they may need educating, frogmarching to the gym. Or is it just a product of modern culture?
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RE: The fatso gene and a fat gene discussion - May 1 2008 18:14:50
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David Barr
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Naw, evolutionarily speaking it's great for survival... that is to say it was great. 
quote:
ORIGINAL: James
Although for sure diet, exercise and lifestyle are primary reasons for obesity, is the fatso gene a 'genetic nudge' in the wrong direction?
Are there any specifics on how the gene(s) work?
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RE: The fatso gene and a fat gene discussion - May 2 2008 12:48:55
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James
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On the FTSO gene - I have no info on how it works - I'm looking for more info
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RE: The fatso gene and a fat gene discussion - May 2 2008 18:38:18
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Andy26
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this is very interesting. .
In my opinion it is far to early to be speculating as to what role this FTSO gene has, if any in the obesity of individuals and whether or not they are genetically predisposed to obesity.
Firslty they need to identify the transcript from this gene, identify/purify the transcript if able to do so, assay the transcript to see what signalling pathways/molecular interactions it is involved in. What effect over/under transcription of this gene has. So to say at this stage they have identified a gene that predisposes people to obesity is in my opinion far reaching and with no research to back up their findings there is alot of work to be done.
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RE: The fatso gene and a fat gene discussion - May 4 2008 14:03:12
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James
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Thanks Andyb - good links - that'll be the one
Other Andy - good thoughts too.
I'll have a deeper read now I have those links.....
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RE: The fatso gene and a fat gene discussion - May 4 2008 23:29:55
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zooma
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Does this gene have any influence on metabolism?
(ive wondered why my metabolism is so slow. [RMR is 1650kcal])
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