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Receptor saturation or long term use

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stewedw
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2015/01/03 12:37:33 (permalink)
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Receptor saturation or long term use

Hi guys. I know a lot of mates and friends of friends who have started out a cycle or so. The gains they ate making are excellent. Maybe 5+ years of training before looking at gear and now three cycles in they "look" the way they want.

I've been going to the gym for 18 years now and this year's from may to August I ran 1g test, diet and training went well. However physical changes were minimal. Weight gain was mild and could be excess water or stored carbs.

So essentially I'm wondering of my body is simply resistant to aas or has built up a tolerance? I ask as I'm using the same brands at a higher dose yet not seeing any effect, and I eat well compat d to the people that are doing excellent as far as body comp changes go. I successfully ran a keto three times getting to single digit bodyfat in less than ten weeks the first time (from 22%) and then from 15 to 9% in four weeks the second time so I appear to be doing well as far as cutting goes. However I have a picture of me at 13.5 stone and another St 14.5stone which look almost identical.

Any thoughts?

A typical cycle would be up to 1g test and 300-600 of deca or tren. Sometimes dbol, I always kick-start and I cruise at 250mg for a while when I am cruising

Should I come off and give myself six months natty and go back on, or stack different etx?

Cheers
post edited by stewedw - 2015/01/03 12:39:29

Stats:

Bench: 165Kg 1RM
Squat: 190Kg 1RM
Deadlift: 220kg 1RM
#1

6 Replies Related Threads

    Dumbat
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    Re: Receptor saturation or long term use 2015/01/03 12:58:04 (permalink)
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    Personally I do not believe the Receptor saturation theory.
    Gains will slow down as one progresses, look at the top professional BBers, a gain of 5 lbs of LBM in a year is considered good for them.
    While we do overcome some of our genetic limits through AAS use there are still factors that will limit the amount of muscle mass that we can obtain and maintain. 
    Growth is an exponential process with gains becoming exponentially less as AAS use has to become exponentially greater.
    (More for less)
     
    Going "natty" will only result in loss of mass , you would still have to run high doses of AAS to get to your goals.
     
    As for the appearance issue, yes the changes will be less noticeable as one progresses as the gains will be proportionally less ( a lower percentage of what one already has) 
    The addition of other compounds can help, HGH, Peptides,  insulin etc.  
    post edited by Dumbat - 2015/01/03 13:05:24

    Ignorance: Reassuringly Expensive.






    #2
    Uriel
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    Re: Receptor saturation or long term use 2015/01/03 14:26:54 (permalink)
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    As above, receptor saturation is a myth. The whole concept is shaky at best, saturated receptors means a hormone bound to every single receptor in the body, which means maximal effect. Since people taking 2g of gear bump it up to 4g and still notice a difference, then obviously they weren't saturated before. In fact research indicates that in the presence of high amounts of anabolic steroids the body actually creates new receptors to accommodate so saturating the receptors may not be possible at all.
     
    Gains simply slow down as you progress, with or without gear. With gear the ceiling is just set higher, and more so the more gear you use.
    #3
    Dumbat
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    Re: Receptor saturation or long term use 2015/01/03 14:48:05 (permalink)
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    Uriel
    As above, receptor saturation is a myth. The whole concept is shaky at best, saturated receptors means a hormone bound to every single receptor in the body, which means maximal effect. Since people taking 2g of gear bump it up to 4g and still notice a difference, then obviously they weren't saturated before. In fact research indicates that in the presence of high amounts of anabolic steroids the body actually creates new receptors to accommodate so saturating the receptors may not be possible at all.
     
    Gains simply slow down as you progress, with or without gear. With gear the ceiling is just set higher, and more so the more gear you use.




    I concurr with this belief: Scientific evidence is limited however there is no scientific evidence that disproves this hypothesis. I believe this to be the main reason that novice AAS users who choose to run high doses of AAS find they do not benefit from the same results as seasoned users do. 

    Ignorance: Reassuringly Expensive.






    #4
    gym3timesaweek
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    Re: Receptor saturation or long term use 2015/01/04 23:21:43 (permalink)
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    i always puzzled myself over the recepter theory but ive been told by many it wont happen but also told by many to give a rest as they get blocked 
    #5
    Uriel
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    Re: Receptor saturation or long term use 2015/01/05 08:07:03 (permalink)
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    Yeah throughout the cycle they get blocked by the steroid molecules...which is the whole point, that's the only way they do anything. Steroid molecule binds to androgen receptor, hormone-receptor complex migrates to the nucleus of the cell where it interacts with DNA and the good stuff happens.
     
    Free receptors means nothing happening.
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    stewedw
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    Re: Receptor saturation or long term use 2015/01/06 14:17:08 (permalink)
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    good replies guys, its what I was thinking as I read up a lot about this stuff, but also know folk who run 750mg pharama gear with small amounts of gh (2-4iu daily) and they appear to be growing good lean muscle. Clearly though there will always be other variables as you learn how to eat better, sleep better and train better.  I'll do a 6 week cut then rebound and run a decent dose of gear and see how I get on. I'll keep a food diary this time as it worked when I did one before, and this way nothing is left to chance :-)

    Stats:

    Bench: 165Kg 1RM
    Squat: 190Kg 1RM
    Deadlift: 220kg 1RM
    #7
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