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Helpful ReplySARM LGD-4033 jw supplements

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2014/12/27 17:07:37 (permalink)
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SARM LGD-4033 jw supplements

Anyone have any feedback on SARM LGD-4033? I just had an e-mail from jws re this product - looks quite interesting...
 

Product Description

WARNING:
This product is not for human consumption.
 
LGD-4033 is a selective androgen receptor modulator (SARMS), and a novel non-steroidal oral SARM that binds to AR with high affinity (Ki of ~1 nM) and selectivity. It’s in a class of androgen receptor (AR) ligands that is tissue selective, developed to treat muscle wasting associated with cancer, acute and chronic illness and age-related muscle loss. LGD-4033 is expected to produce the therapeutic benefits of testosterone with improved safety, tolerability and patient acceptance due to tissue-selective mechanism of action and an oral route of administration.

How it works
LGD-4033, a novel nonsteroidal, oral selective androgen receptor modulator, binds to the androgen receptor with high affinity and selectivity. It demonstrates anabolic activity in muscles, anti-resorptive and anabolic activity in bones and a robust selectivity for muscle and bone versus prostate and sebaceous glands. LGD-4033 has recently completed a Phase I Multiple Ascending Dose study in healthy volunteers.  This randomized, double-blind, placebo-controlled Phase I study established the safety and tolerability up to doses of 22 mg per day.
Uses
LGD is still fairly new (3-5 years), but the results have been very similar in studies and logs. LGD-4033 has undergone several recent studies and trials to find the best and safest way to use it. From these trials, the results have shown increases in lean body mass and decreases in body fat. There is also a significant increase in strength, well being, as well as healing possibilities.
Bulking
LGD has shown the most ability of any SARM to put on size that could be considered a bulk. This will, of course, be dependent upon the diet used. Users that have experienced more than 10lb. increases, and have had a significant increase in calorie intake. The possibility of this type of size is present with LGD use. A recommend dosage for this type of goal would be 5-10 mg day for 8 weeks.
 
 

Recomp
LGD seems to shine with this method. Many have seen an increase in lean body mass and a decrease in body fat. LGD seems to work the best with this method. Ran in conjunction with other SARMS, like cardarine (GW-501516), will only increase the likelihood of a stronger recomp. Recommended doses for recomping would be 5-8 mg a day for 8 weeks.
Cutting
LGD can be used to cut as well. It will shine more-so if ran in conjunction with SARMS S-4 and Cardarine (GW-501516). This would be similar to a SARMS triple stack that is normally ran with Ostarine, except there is a possibility of more size being put on while cutting. A good dose for this method would be 3-5 mg a day for 8 weeks.
Side Effects
Through studies and logs, the side effects from LGD have so far shown to be minimal. The suppression shown has been dose dependent, but there has been a decrease in total and free testosterone as well as SHBG. These interesting findings have show NO significant decrease in LH or FSH. This is very encouraging to users as it shows that while suppressive, recovery will still not be near as long as with anabolic steroids. LGD is non toxic and side effects have been mild to minimal. It has not shown increases in estradiol ,but, as with anything, an aromatase inhibitor should be kept on hand.
A full pct, as opposed to a mini pct with other SARMS, is recommended after a cycle of LGD. While it may not be quite as suppressive as anabolics, the suppression is much higher than other SARMS, thus, requiring a full PCT.
LGD-4033 Summary
Effects similar to anabolics with size and strength
Minimal Side Effects
Excellent for recomping
Healing properties
Prevents muscle wasting
Works well as a stand alone or stacked with other SARMS
Great results in every aspect for different types of goals
Half life of 24-36 hours
 
Serving Size: 1 Capsule
Servings Per Container: 90 Capsules
Amount per Serving                         %DVA
LGD-4033                        3mg            *
4-((R)-2((R)-2,2,2-trifluoro-1-hydroxyethyl)pyrrolidin-1-yl)-2-trifluoroMethyl)benzonitrile
 
*Daily Value not Established
Other Ingredients: Rice Flour, Magnesium Stearate, Gelatin
#1
Hispano
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Re: SARM LGD-4033 jw supplements 2014/12/27 18:09:49 (permalink)
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I used ostarine half year ago and to be honest,i didnt notice anything at all so save the money to buy M-Dien,M1T or similar PH´s that really do something
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Kaneda
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Re: SARM LGD-4033 jw supplements 2014/12/27 19:12:13 (permalink)
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I found ostarine to be pretty good tbh
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Re: SARM LGD-4033 jw supplements 2014/12/27 19:54:32 (permalink)
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I have also used Ostarine (Armour from Bodyconscious - 3xtab = 15mg/day) - didn't notice much myself, but LGD sounds like it is a bit more potent?
#4
Hispano
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Re: SARM LGD-4033 jw supplements 2014/12/27 20:24:30 (permalink)
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10 lb 8 weeks...M1T can put 15 lb in 1 month...
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vanderlei
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Re: SARM LGD-4033 jw supplements 2014/12/28 13:22:28 (permalink)
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M1T is a very potent drug, u can not compere it to Sarms like osta or LG!
If I can gain 10lb on osta in 8 weeks that would be my pick over M1t but that is just me;)

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Re: SARM LGD-4033 jw supplements 2014/12/28 20:41:47 (permalink)
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vanderlei
M1T is a very potent drug, u can not compere it to Sarms like osta or LG!
If I can gain 10lb on osta in 8 weeks that would be my pick over M1t but that is just me;)


+1, hence my interest in LGD. Apart from being "NOT FOR HUMAN CONSUMPTION"....
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simonboyle
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Re: SARM LGD-4033 jw supplements 2014/12/29 11:56:57 (permalink)
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google it, there are logs on some american sites.
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Re: SARM LGD-4033 jw supplements 2014/12/29 20:39:55 (permalink)
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simonboyle
google it, there are logs on some american sites.


Will do, thanks. What's your opinion on LGD?
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simonboyle
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Re: SARM LGD-4033 jw supplements 2014/12/29 20:48:12 (permalink)
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never used it buddy.
used osta several times, love it
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simonboyle
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Re: SARM LGD-4033 jw supplements 2014/12/29 22:05:43 (permalink)
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vanderlei
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Re: SARM LGD-4033 jw supplements 2014/12/30 05:43:25 (permalink)
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simonboyle
http://www.ncbi.nlm.nih.gov/pubmed/22459616

Looks good just hope that they don't work for the owner of a product as we all know some studies are "supervised"by manufacturers;)

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simonboyle
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Re: SARM LGD-4033 jw supplements 2014/12/30 09:35:44 (permalink)
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Nah, genuine placebo controlled study.
click author info.
there are others too.
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rokkus3
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Re: SARM LGD-4033 jw supplements 2014/12/30 14:03:00 (permalink)
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I'd be tempted to run this at a moderate dose (~5mg) for 4-6 weeks and then follow it up with 4 weeks Osta... maybe even cycling the combination twice i.e. 4 weeks LGD, 4 weeks Osta, 4 LGD, 4 Osta etc.
 
Although if you're wanting it to 'bulk' then you're probably going to need to up that dose and I wouldn't consider running the combo twice over. IIRC, Ligand (the folk who initially developed the compound), say doses are well tolerated up to 22mg/day but I wouldn't advise going up there as IMO you'd be better off with AAS or OTC PH's (better gains/cost/'known' sides).  This is a new compound after all and still causes some suppression.  Personally I'd much rather stick to the tried and tested (depending on how reliable your AAS source is of course) when playing with higher doses.

"Fatigue makes cowards of us all" - Vince Lombardi

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simonboyle
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Re: SARM LGD-4033 jw supplements 2014/12/30 19:14:36 (permalink)
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Causes more suppression than osta at 1mg.
but I run a serm with my sarms
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rokkus3
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Re: SARM LGD-4033 jw supplements 2014/12/30 20:08:01 (permalink)
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^ I don't think you need a SERM after Osta, IMO that's overkill.  Whatever suits you tho I guess.
 
 

"Fatigue makes cowards of us all" - Vince Lombardi

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simonboyle
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Re: SARM LGD-4033 jw supplements 2014/12/30 20:36:25 (permalink)
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yeah, like to be safe. plus a SERM is a PED too.
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Re: SARM LGD-4033 jw supplements 2015/01/01 20:11:07 (permalink)
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Happy New Year all!
 
I've not had time to read too much into LGD yet, but what i have read it sounds like an interesting alternative to AAS and PH's. Most of the info i have read has been of users using a liquid rather than tablet though - not sure if this makes much difference? Jury is still out on whether or not a SERM is needed for PCT? I appreciate It's not a wonderdrug (non liver toxic, shorter recovery times etc) otherwise we'd all be jumping on it, but if it works then it must come with some cautions. I need to read more on it but am definitely interested in giving it a go.  
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alekan
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Re: SARM LGD-4033 jw supplements 2015/01/01 21:01:52 (permalink)
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It is full suppressive at doses that worth it, and for long runs (8 weeks etc) I've read some bad stuff, like side effects of no test in your body. Maybe it is ok for shorter runs, not like osta (which rocks btw)
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Re: SARM LGD-4033 jw supplements 2015/01/02 20:23:18 (permalink)
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alekan
It is full suppressive at doses that worth it




What kind of doses we talking?
#20
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