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Superdrol Half life confusion and PCT

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mattbodom
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2015/02/19 10:44:32 (permalink)
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Superdrol Half life confusion and PCT

Hi i am 24 years old, i train, eat and sleep well and i am thinking about doing a 2-3 week cycle of S-drol and i have Nolva along with Reversitol V2 for PCT. The half life of S-drol is 8-10 hours so it makes sense to take one cap in morning and another 8 hours later. However, each cap is 12mg, so obviously 2 caps is 24mg :p. For my first cycle i would like to start off with 1 cap a day for the first week and then 2 caps for the remaining 2 weeks. The thing that is putting me off is the short half life of S-Drol. If i was to take only 1 cap a day in the morning, what would happen after the 8-10 hours that s-drol is fully working? Im mainly worried that after the s-drol has reached its maximum half life i will start to develop gyno or basically just mess the cycle up.. Any help would be great :) 
 
P.S Do you think that 20mg Nolva everyday for 4 weeks afterwards will be a sufficient PCT? Should i include the reversitol V2? Its basically a Natty Test booster with "Anti-Aromatose" Properties and a "natural" SERM.
 
Thankyou
#1
simonboyle
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Re: Superdrol Half life confusion and PCT 2015/02/20 00:43:03 (permalink)
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Don't worry about the half life. You won't get gyno because you're dosing only once a day.
What you plan will be fine.
#2
Uriel
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Re: Superdrol Half life confusion and PCT 2015/02/20 08:13:19 (permalink)
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1) SD half life is not known to be "8-10 hours" or any hard figure like that. In fact I've never seen a study on the pharmacokinetics of superdrol. It's very close cousin methylstenbolone can have a "half life" of around 16 hours and continue to be absorbed for up to two days. These very potent designer steroids owe their potency to their very high resistance to metabolic breakdown, meaning they'll stay in your body for a pretty long time, repeatedly binding to receptors until they're gone.
 
2) "Half life" is a scientific concept, mainly used in nuclear research, that means the time it takes for a certain amount of substance to decay to half its original mass. It's very useful for this purpose because radioactive substances follow a very well defined and predictable inverse exponential decay pattern, knowing the half life of a substance you can calculate how much you'll have at any time. The concept is sometimes used in pharmacology but people need to realize that here it's not taken anywhere near as seriously because drug decay in a living organism does not follow such a neat elimination pattern. If the half life of superdrol was 8 hours, and it decayed perfectly like a radioactive substance (which it doesn't), it just means that 8 hours later you'd have half as much SD in your system as you did when you took it, meaning it's still working, just not as much.
 
But this is all pointless anyway because like I said these substances will have a fairly unpredictable elimination pattern, a drug may have a "half life" of 8 hours but decay very slowly after that and at the 20 hour mark still have plenty of it in you, or decay very fast and have a "half life" of 8 hours and at the 10 hour mark it's mostly gone. There may also be biphasic patterns (levels drop and later increase again) and with orals virtually anything you eat can affect absorption rate (caffeine has been shown to increase absorption rate of oral steroids dramatically, for instance). This variability makes the whole concept of half life nearly useless for biochemistry. It's still used so heavily on steroid forums because, as they say, a little knowledge is a dangerous thing.
post edited by Uriel - 2015/02/20 08:18:55
#3
Uriel
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Re: Superdrol Half life confusion and PCT 2015/02/20 08:13:19 (permalink)
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.
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simonboyle
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Re: Superdrol Half life confusion and PCT 2015/02/20 09:52:16 (permalink)
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My understanding was it referred to elimination half life
#5
Uriel
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Re: Superdrol Half life confusion and PCT 2015/02/20 09:59:56 (permalink)
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"Elimination half-life" is the technical term for the equivalent in biology to radioactive decay half-life. It's the time it takes for the concentration of the substance in the blood to reach half it's peak value. Everything I said still applies, it's very vague information to the point of being useless because it only tells you the concentration of the substance at a very specific time, says nothing about how much you'll have before of after that.
#6
simonboyle
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Re: Superdrol Half life confusion and PCT 2015/02/20 10:09:54 (permalink)
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Yup. But elimination half life is linear, as it is a chemical and filtering process it is going through, as opposed to curvilinear due to decay?
#7
Uriel
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Re: Superdrol Half life confusion and PCT 2015/02/20 10:49:50 (permalink)
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That's just it, it's not linear, it doesn't really follow any mathematical prediction at all. Two different substances can have completely different pharmacokinetics. Oral AAS usually peak several hours post ingestion (any mathematical half-life prediction assumes peak value from the start), and both absorption and elimination can vary greatly not only between individuals, but even from day to day for the same person.
#8
simonboyle
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Re: Superdrol Half life confusion and PCT 2015/02/20 10:59:01 (permalink)
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Yup.
More linear than decay then.
#9
Uriel
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Re: Superdrol Half life confusion and PCT 2015/02/20 12:54:03 (permalink)
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Well if you call something like this linear:

(squares)
 
More like a negative quadratic up until the 18h mark, then somewhat linear until 30-ish hours.
#10
KS_Manchester
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Re: Superdrol Half life confusion and PCT 2015/02/20 12:59:44 (permalink)
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Sweet - caffeine improves oral steroid absorbtion.

That's me sorted (all i needed to know)



K
#11
Uriel
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Re: Superdrol Half life confusion and PCT 2015/02/20 13:05:31 (permalink)
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KS_Manchester
Sweet - caffeine improves oral steroid absorbtion.

That's me sorted (all i needed to know)



K

Absorption rate. Doesn't necessarily mean you'll absorb more total substance from what you take, just that you'll take it in and process it faster.
#12
simonboyle
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Re: Superdrol Half life confusion and PCT 2015/02/20 13:38:43 (permalink)
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Yeah, specific terms fail me at the moment. Not linear, but more straight forward than nuclear decay.
But agree, my original point was to not worry about it.
#13
Uriel
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Re: Superdrol Half life confusion and PCT 2015/02/20 13:52:44 (permalink)
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Yeah once a day is perfectly fine.
 
In fact I sometimes dose orals once a day even when I could split it out, precisely to avoid having very high levels of it during the evening and night time and having it interfere with my sleep. Hard to make gains if you can't sleep, and SD does keep me awake.
post edited by Uriel - 2015/02/20 13:54:06
#14
simonboyle
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Re: Superdrol Half life confusion and PCT 2015/02/20 14:01:15 (permalink)
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Snap. Once per day unless issues arise
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mattbodom
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Re: Superdrol Half life confusion and PCT 2015/02/27 14:15:38 (permalink)
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Thankyou everyone, i think i understand now haha. I have just got my On cycle support so i am going to start tomorrow, or maybe even tonight. What would be the best time to take it if i am only dosing 1 a day? I am going to take 2 after the first 4-7 days. Thanks again
#16
simonboyle
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Re: Superdrol Half life confusion and PCT 2015/02/27 14:27:22 (permalink)
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take it with a meal. not really important when
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