Re: Triptorelin vs. Gonadorelin
(permalink)☄ Helpfulby robert123 2015/02/28 12:50:12
Single dose of triptorelin gets bodybuilder’s hormones going againItalian endocrinologists managed to restore the natural testosterone production of a bodybuilder whose sex hormone production had shut down after 13 years of taking steroids. All they had to do was give the 34-year-old man a single dose of 100 micrograms triptorelin. An article by the researchers, who work at the University of Brescia, was published recently in Fertility & Sterility. The bodybuilder went to a doctor in September 2008 because he was depressed, had no energy and had lost all interest in sex. He told the doctor he’d been using steroids since he was 21.The guy took 10-week courses. Typically he would inject a daily 25 mg nandrolone and 25 mg stanozolol for the first 8 weeks, and follow it with 2 weeks of 50 mg mesterolone daily [say: primo]. The following week he would take 50 mg clomid daily, and for the last week he’d inject himself three times with 2000 IE hCG.Well, that’s what the doctors reported. Probably the man took hCG first and clomid after. What’s more the doses sound very responsible to us. If bodybuilders tell doctors how much steroids they’ve been using, in our experience you need to triple the doses.How many courses the man took each year is also not mentioned in the article.The bodybuilder did jack up his doses from 2005 to 2008. During the 8 weeks that he injected stanozolol and nandrolone, he also started to use boldenone, injecting an average of 50 mg per day for a period of 3 weeks. And that’s where it went wrong, according to the blood tests. The doctors examined the guy in September, but decided to just observe for a few months. A damaged axis often just needs time to recover. But when the doctors examined the bodybuilder’s blood again in January 2009, there had been hardly any improvement.
The doctors decided to treat the guy with the GnRH analogue triptorelin. GnRH is a hormone that consists of only 10 amino acids. It is produced in the brain by the hypothalamus and stimulates the production of FSH and LH by the pituitary gland. The hormones travel in the blood to the sex glands, where they get these to produce testosterone.The bodybuilder responded immediately to the hormone treatment. Within several minutes the concentration of LH and FSH in his blood had risen.
The doctors saw the bodybuilder 10 days later. His energy had returned and the testosterone concentration in his blood had risen to 7 ng/ml. Another three weeks later, his testosterone level was still normal, and his libido had returned too.Source:
Fertil Steril. 2010 Apr 21. [Epub ahead of print].
Vitamin E protects testes while taking steroids 26.03.2010
Case study: hCG restores testosterone production after steroids use 26.02.2010
Case study: clomid normalises bodybuilder’s hormone levels 20.02.2010
Animal study: running reduces effect of steroids on testes 15.02.2010
Getting older? Take anti-oestrogens with your testosterone 22.12.2009
Testicle size worries? Try a course of Nolvadex + Andriol 20.08.2009
Cell doping in the lab 29.07.2009
Recovery from mild nandrolone use takes six months 13.12.2008
Bodybuilder on hCG almost loses last testicle 30.10.2008 VS GONA Cailleux-Bounacer A, Reznik Y, Cauliez B, Menard JF, Duparc C, Kuhn JM. Evaluation of endocrine testing of Leydig cell function using extractive and recombinant human chorionic gonadotropin and different doses of recombinant human LH in normal men.Eur J Endocrinol 2008;159(2):171-8. Evaluation of endocrine testing of Leydig cell function using extractive and recombinant human chorionic gonadotropin and different doses of recombinant human LH in normal men -- Cailleux-Bounacer et al. 159 (2): 171 -- European Journal of Endocrinol
BACKGROUND: The functional testing of endocrine testis uses extractive human chorionic gonadotropin (ehCG). Recombinant human hCG (rhCG), avoiding any contamination, should replace ehCG. Moreover, a functional evaluation with recombinant human LH (rhLH) would be closer to physiology than a pharmacological testing with hCG.
METHODS: The study was conducted in normal men. We first evaluated the dose-effect of ehCG on plasma testosterone and estradiol levels, before and after injection of either hCG or vehicle. Secondly, the responses to the optimal dose of ehCG were compared with those of rhCG. Thirdly, we investigated the dose-effect of rhLH, on steroid hormone secretion. LH, testosterone, and estradiol plasma levels were measured after the injection of either rhLH or placebo.
RESULTS: ehCG induced dose-dependent increases in plasma estradiol and testosterone levels. They respectively peaked at 24 and 72 h after the injection. The most potent dose of ehCG (5000 IU) induced results similar to those observed with 250 microg (6500 IU) rhCG. By comparison with placebo, rhLH induced a significant and dose-dependent increase in plasma testosterone levels 4 h after the injection. Peak response of testosterone to rhLH and rhCG was significantly correlated. rhLH did not induce significant change in plasma estradiol level.
CONCLUSIONS: In normal men, a single i.v. injection of 150 IU rhLH induces a 25% rise in plasma testosterone levels by comparison with placebo. At the moment, the dynamic evaluation using hCG remains the gold standard test to explore the Leydig cell function. The use of 250 microg rhCG avoiding any contamination should be recommended.
Handelsman DJ, Goebel C, Idan A, Jimenez M, Trout G, Kazlauskas R. Effects of recombinant human LH and hCG on serum and urine LH and androgens in men. Clin Endocrinol (Oxf) 2009;71(3):417-28.
CONTEXT: The administration of gonadotrophins is prohibited in sport but the effect in men of recently available recombinant hCG and LH on serum and urine concentrations of gonadotrophins and androgens has not been systematically evaluated in the antidoping context.
OBJECTIVE: To determine the time-course of recombinant LH (rhLH) and hCG (rhCG) on blood and urine hormone profiles in men to develop effective tests to detect rhLH and rhCG doping.
DESIGN: Two randomized controlled studies with a 2 x 2 factorial design.
SETTING: Academic research centre.
PARTICIPANTS: Healthy male volunteers aged 18-45 years.
INTERVENTIONS: In the rhLH study, men were randomized into (i) either of two single doses of rhLH (75 IU or 225 IU), and (ii) suppression of endogenous LH and testosterone by nandrolone or no suppression. In the rhCG study, men were randomized into (i) either of two single doses of rhCG (250 or 750 microg), and (ii) suppression of endogenous LH and testosterone by nandrolone decanoate (ND) or no suppression. ND suppression comprised a single dose of 200 mg ND 3 days prior to, and in the rhCG study an additional dose 1 day after gonadotrophin injection.
MAIN OUTCOME MEASURES: Serum and urine hCG, LH, T, T : LH ratio, urine epitestosterone (E) and urine T : E ratio. RESULTS: Neither rhLH dose produced a significant increase in serum or urine LH or T or in the T : E or T : LH ratios regardless of ND-induced suppression of endogenous LH and T. Nor did an even higher dose (750 IU) in three healthy men with unsuppressed gonadal axis. These findings were confirmed with two different commercial LH immunoassays together with adjustment for any influence of urine sediment and dilution. Both rhCG doses produced a steep, dose-proportional increase in serum and urine hCG with increases in serum and urine T and suppression of serum and urine LH, regardless of hCG dose. Serum but not urine T was lowered by ND suppression. The T : LH ratio showed a progressive increase unrelated to rhCG dose or ND suppression, whereas both rhCG and ND suppression minimally increased T : E ratio.
CONCLUSIONS: Both rhCG doses produce a striking increase in serum hCG and T with suppression of serum LH but, at single doses up to 750 IU, rhLH has no influence on serum or urine LH or T. Effective rhLH doping, which relies on a sustained increases in endogenous T, would require much higher and more frequent daily rhLH doses. Use of LH immunoassays optimized for serum to detect rhLH doping by urine LH measurement requires more standardization and validation and, at present, is unreliable. The T : LH ratio is, however, a useful screening test for hCG doping although its utility requires further evaluation.