personally no. i've been tested on and off cycle and had no problems what so ever even when using winny which is apparently very bad for your lipid levels.
the trick is to get tested mate so you know you don't have a problem! alternatively there are some over the counter cholesterol reducing drugs which you could incorporate into your cycle if you're very worried.
AKA theweeninjaguy. 8 st 2 lb when I joined this site, I’ve gained 7 stone + since then.