YB
BannerBanner

high-phenol extra-virgin olive oil reduces oxidative DNA damage

Author
James
Owner & Moderator
  • Total Posts : 50863
  • Reward points: 14530
  • Joined: 2000/11/10 18:09:18
  • Location: Northants, UK
  • Status: offline
2006/07/11 15:38:03 (permalink)

high-phenol extra-virgin olive oil reduces oxidative DNA damage

Daily consumption of a high-phenol extra-virgin olive oil reduces oxidative DNA damage in postmenopausal women

Authors: Salvini, Simonetta1; Sera, Francesco1; Caruso, Donatella2; Giovannelli, Lisa3; Visioli, Francesco2; Saieva, Calogero1; Masala, Giovanna1; Ceroti, Marco1; Giovacchini, Valentina1; Pitozzi, Vanessa3; Galli, Claudio2; Romani, Annalisa4; Mulinacci, Nadia4; Bortolomeazzi, Renzo5; Dolara, Piero2; Palli, Domenico1

Source: British Journal of Nutrition, Volume 95, Number 4, April 2006, pp. 742-751(10)

Publisher: CABI Publishing


Abstract:

Extra-virgin olive oils (EVOO), high in phenolic compounds with antioxidant properties, could be partly responsible for the lower mortality and incidence of cancer and CVD in the Mediterranean region. The present study aims to measure oxidative DNA damage in healthy human subjects consuming olive oils with different concentrations of natural phenols. A randomised cross-over trial of high-phenol EVOO (high-EVOO; 592 mg total phenols/kg) v. low-phenol EVOO (low-EVOO; 147 mg/kg) was conducted in ten postmenopausal women in Florence. Subjects were asked to substitute all types of fat and oils habitually consumed with the study oil (50 g/d) for 8 weeks in each period. Oxidative DNA damage was measured by the comet assay in peripheral blood lymphocytes, collected at each visit during the study period. Urine samples over 24 h were collected to measure the excretion of the olive oil phenols. The average of the four measurements of oxidative DNA damage during treatment with high-EVOO was 30 % lower than the average during the low-EVOO treatment (P=0·02). Urinary excretion of hydroxytyrosol and its metabolite homovanillyl alcohol were significantly increased in subjects consuming high-EVOO. Despite the small sample size, the present study showed a reduction of DNA damage by consumption of an EVOO rich in phenols, particularly hydroxytyrosol.

James Collier - MuscleTalk Co-Owner
@JamesCollierMT


#1

7 Replies Related Threads

    USA DEALS
    ginasmg
    Pro-Member
    • Total Posts : 23375
    • Reward points: 8862
    • Joined: 2006/06/24 01:20:06
    • Location: yorkshire
    • Status: offline
    RE: high-phenol extra-virgin olive oil reduces oxidative DNA damage 2006/07/11 20:00:39 (permalink)
    were there any studies done in labratory conditions where the subjects could be monitord to ensure full complience with the subject conditions no cheating etc?are they saying that cancer is connected to dna damage?
    #2
    James
    Owner & Moderator
    • Total Posts : 50863
    • Reward points: 14530
    • Joined: 2000/11/10 18:09:18
    • Location: Northants, UK
    • Status: offline
    RE: high-phenol extra-virgin olive oil reduces oxidative DNA damage 2006/07/12 14:30:33 (permalink)
    were there any studies done in labratory conditions where the subjects could be monitord to ensure full complience with the subject conditions no cheating etc?

    Not in this case. It is really hard to do a study like this - drop out rate would be high unless sujects were paid a huge wage. So unfortunately free-living subject studies are far more common.

    are they saying that cancer is connected to dna damage?

    In part

    James Collier - MuscleTalk Co-Owner
    @JamesCollierMT


    #3
    ink
    Pro-Member
    • Total Posts : 3118
    • Reward points: 5415
    • Joined: 2002/02/26 13:26:42
    • Location: Location not known
    • Status: offline
    RE: high-phenol extra-virgin olive oil reduces oxidative DNA damage 2006/07/12 14:37:36 (permalink)
    James, which EVOOs are higher in phenols?
    #4
    James
    Owner & Moderator
    • Total Posts : 50863
    • Reward points: 14530
    • Joined: 2000/11/10 18:09:18
    • Location: Northants, UK
    • Status: offline
    RE: high-phenol extra-virgin olive oil reduces oxidative DNA damage 2006/07/12 14:40:12 (permalink)
    I really do not know TBH Ink - sorry and I'm not sure where to find out from
    #5
    ink
    Pro-Member
    • Total Posts : 3118
    • Reward points: 5415
    • Joined: 2002/02/26 13:26:42
    • Location: Location not known
    • Status: offline
    RE: high-phenol extra-virgin olive oil reduces oxidative DNA damage 2006/07/12 14:41:52 (permalink)
    I think I'll try a search . These results may then apply to any foods which are rich in phenols, green tea, cinnamon...
    #6
    ink
    Pro-Member
    • Total Posts : 3118
    • Reward points: 5415
    • Joined: 2002/02/26 13:26:42
    • Location: Location not known
    • Status: offline
    RE: high-phenol extra-virgin olive oil reduces oxidative DNA damage 2006/07/12 14:50:37 (permalink)
    Nothing on EVOO sources, but here's an interesting related study:

    http://www.jacn.org/cgi/content/full/22/3/217
    #7
    JKJ
    Pro-Member
    • Total Posts : 2178
    • Reward points: 6002
    • Joined: 2004/11/10 05:08:09
    • Status: offline
    RE: high-phenol extra-virgin olive oil reduces oxidative DNA damage 2006/07/12 16:56:55 (permalink)
    would be interesting to see the effects of supplementation of just the phenols

    good/evil/dont know
    #8
    Jump to:
    ©2017 All content is copyright of MuscleTalk.co.uk and its use elsewhere is prohibited.
    (posting guidelines | privacy | advertise | earnings disclaimer | contact us | supported by)
    © 2017 APG vNext Commercial Version 5.5