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Answeredsteroids in puberty, penis size,AR-downregulation

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sickert
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2014/11/25 11:12:27 (permalink)

steroids in puberty, penis size,AR-downregulation

hi

I got a question and the forum members have the expertise to answer that based on own experiences.

You probably know people who did steroids in puberty (let us say a conventional steroid).
Has their penis considerably grown based on your experiences?
We all know that peripuberal variance of hormonal levels should in part result in the variance of final penis size, however current research hints at the fact that eugonal levels ,even low range, might be sufficient to reach one ´s "predetermined" penis size ,just changing the pace of puberty and the point of time of final bone-ossification et cetera.

there seems to be some prenatal effects in place determining the final size.

The thoughts about it and the articles:

.ncbi.nlm.nih.gov/pmc/articles/PMC2816361/"

"Foetal and/or postnatal TP exposure does not increase adult penile size above its ‘predetermined’ length though its growth towards this maximum is advanced by peripubertal TP treatment."

Those are just rats ,though.



ncbi.nlm.nih.gov/pubmed/9258152

"These experiments support the hypothesis that penile growth cessation is mediated by mechanisms other than down regulation of the androgen receptor. "

the down-regulation is not the cause for the end of penis growth ,apparently, so there is not an androgen-mediated stop and raising the level in puberty ,even in the high range, would not yield any benefits.


You could probably help me with the experiences you and friends made in various gyms.

Thankyou
#1
Valley Fitness
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Re: steroids in puberty, penis size,AR-downregulation 2014/11/25 19:27:22 (permalink)
Yes my cock is like an elephants, I took a lot of gear during puberty and some pre natal so you must be on to something
#2
Medic
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Re: steroids in puberty, penis size,AR-downregulation 2014/11/25 20:27:38 (permalink)
Wahahaha
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n i n j a
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Re: steroids in puberty, penis size,AR-downregulation 2014/11/26 11:49:52 (permalink)
whit?
 
i too have a massive cock!
 
lol
 
seriously tho man, is this a serious question?
 
ninja

AKA theweeninjaguy.  8 st 2 lb when I joined this site, I’ve gained 7 stone since then. Homer stands behind me as a reminder that a normal 44 year olds body is constantly chasing me. The only difference between me and homer, is MT and the gym!
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Dumbat
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Re: steroids in puberty, penis size,AR-downregulation 2014/11/26 14:06:19 (permalink)
Note the age of the patients,
http://europepmc.org/abstract/MED/8326617
 
Prepubescent subjects can be helped with Testosterone administration.
Adult males cannot.
 

Ignorance: Reassuringly Expensive.






#5
sickert
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Re: steroids in puberty, penis size,AR-downregulation 2014/11/26 15:08:51 (permalink)
Dumbat
Note the age of the patients,
http://europepmc.org/abstract/MED/8326617
 
Prepubescent subjects can be helped with Testosterone administration.
Adult males cannot.
 




They were deficient. The question would be if eugonadal athletes benefited from simply raising levels?
In that study the growth rate is not constant though it does not grow to the floor.
 
#6
Dumbat
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Re: steroids in puberty, penis size,AR-downregulation 2014/11/26 17:10:29 (permalink) ☼ Best Answerby sickert 2014/11/26 19:05:00
" />

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#7
sickert
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Re: steroids in puberty, penis size,AR-downregulation 2014/11/26 19:05:26 (permalink)
That is a serious question
 
You cannot tell me you guys do not have any gossip about it
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n i n j a
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Re: steroids in puberty, penis size,AR-downregulation 2014/11/26 22:52:50 (permalink)
tbh we're just trying to decide if your taking the pi55
 
if you'd been on here for a while then we'd actually have answered with a serious reply but as a first ever post this is up there with "i've taken 10mg of dbol for 3 days now but i'm not yet 21 stone - is my gear fake!?"
 
ninja

AKA theweeninjaguy.  8 st 2 lb when I joined this site, I’ve gained 7 stone since then. Homer stands behind me as a reminder that a normal 44 year olds body is constantly chasing me. The only difference between me and homer, is MT and the gym!
#9
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Re: steroids in puberty, penis size,AR-downregulation 2014/11/27 07:54:03 (permalink)
Piss take: Let it die.

Ignorance: Reassuringly Expensive.






#10
sickert
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Re: steroids in puberty, penis size,AR-downregulation 2014/11/27 14:03:30 (permalink)
voodoo ninja
 
if you'd been on here for a while then we'd actually have answered with a serious reply but as a first ever post this is



Why would you base the answer on first post vs. various posts? If you are that knowledgeable simply answer it.
#11
JoshHardcastle
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Re: steroids in puberty, penis size,AR-downregulation 2014/12/10 03:51:22 (permalink)
Androgens act as a triggers to various stages of development, but are not in themselves the determinants of size.  This is easily evidenced by the fact that heavy androgen users do not have further development of the penis.  Early initiation of puberty using androgens is a very risky business, as it can advance steps in the development programming when other required steps have not yet complete. 
 
In the case of prenatal exposure, very serious teratological problems can result for similar reasons ie other developmental programs have not completed, however the magnitude of the effect is much greater.  This can result in obvious problems such as urethral openings being in the wrong place (hypospadias), lack of final secondary sex characteristics ( penis, genitals, etc), neurological problems, or serious disorders of other secreting glands eg( adrenals ).
 
Specifically with the OP, exogenous androgens can be used in some cases where sexual development is stunted, only where the cause of the lack of development is due to androgen insufficiency.  Other cases such as androgen insensitivity, PAIS, etc would be unaffected.  This is definitely something which would need to be undertaken under a specialist/consultant.
 
When considering development of various tissues, one needs to consider the regulatory complexity in their development.  The penis is very tightly regulated (as evidenced by the low incidence of penile cancers).  In comparison, skeletal muscle is an extremely plastic tissue (as is adipose), which is easily changed in response to both endocrinal and metabolic factors.
 
One popular misunderstanding amongst steroid users who claim that their penis has grown on steroids, is the effect of the hormonal changes on the vasomotor function.  That is a transient effect and is fully reversed upon cessation.
 
On a more general note, If your penis is working ie you can pee out of it, and get erections, then I would leave it be, if not then see your GP.  Life is too short to get hung up on the size of your knob, and such insecurities will interfere with your enjoyment of sex and life in general.
 
J
post edited by JoshHardcastle - 2014/12/10 03:54:25

Stop testing on dogs now...
...Your nearest anti-vivisectionist is a far more reliable model.
A representative of MyProtein
Checkout for specials: http://goo.gl/LqsWnL
#12
JoshHardcastle
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Re: steroids in puberty, penis size,AR-downregulation 2014/12/10 03:51:22 (permalink)
...
post edited by JoshHardcastle - 2014/12/10 03:52:49

Stop testing on dogs now...
...Your nearest anti-vivisectionist is a far more reliable model.
A representative of MyProtein
Checkout for specials: http://goo.gl/LqsWnL
#13
sickert
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Re: steroids in puberty, penis size,AR-downregulation 2015/05/09 20:59:30 (permalink)
JoshHardcastle
Androgens act as a triggers to various stages of development, but are not in themselves the determinants of size.  This is easily evidenced by the fact that heavy androgen users do not have further development of the penis.  Early initiation of puberty using androgens is a very risky business, as it can advance steps in the development programming when other required steps have not yet complete. 
 
In the case of prenatal exposure, very serious teratological problems can result for similar reasons ie other developmental programs have not completed, however the magnitude of the effect is much greater.  This can result in obvious problems such as urethral openings being in the wrong place (hypospadias), lack of final secondary sex characteristics ( penis, genitals, etc), neurological problems, or serious disorders of other secreting glands eg( adrenals ).
 
Specifically with the OP, exogenous androgens can be used in some cases where sexual development is stunted, only where the cause of the lack of development is due to androgen insufficiency.  Other cases such as androgen insensitivity, PAIS, etc would be unaffected.  This is definitely something which would need to be undertaken under a specialist/consultant.
 
When considering development of various tissues, one needs to consider the regulatory complexity in their development.  The penis is very tightly regulated (as evidenced by the low incidence of penile cancers).  In comparison, skeletal muscle is an extremely plastic tissue (as is adipose), which is easily changed in response to both endocrinal and metabolic factors.
 
One popular misunderstanding amongst steroid users who claim that their penis has grown on steroids, is the effect of the hormonal changes on the vasomotor function.  That is a transient effect and is fully reversed upon cessation.
 
On a more general note, If your penis is working ie you can pee out of it, and get erections, then I would leave it be, if not then see your GP.  Life is too short to get hung up on the size of your knob, and such insecurities will interfere with your enjoyment of sex and life in general.
 
J





Thanks for the reply. Given i posted several times now ,i think i gained my creds and am to be answered.
 
Concerning the regulatory complexity: I agree with you but i do not think that cancer is a valid indicator here since it seems to mainly affect the skin like skin cancer.
It seems logical that skeletal muscle, way less complex, responds more easily to exogenous hormone injection.
I just do not get why a nonexistent massive penis growth of AAS-users over 25 is a sign that seriously raising the level to the top of the physiological level before age 17 would not result in a penis on the 97. percentile (let s say 7 inch), ignoring the definite dangers of seriously messing up your homeostatis and fertility and bone growth. Assuming the variability of the individual genetic makeup is taken into account.
(I am older and therefore do not plan to do it)
 
 
Concerning the studies originally posted by me:  The androgen receptor downregulation does not seem to coincide with the cessation of penis growth. Does the term down-regulation refer to the number of the receptors or does that also involve changed sensitivity.
 
I thought that guys in this forum know the gossip: There must be some teenagers who actually take steroids aged 15 (though it seems like risky business) ? So have you heard any stories or know exact cases?
 
I am doubting the thesis of the predetermined size (posted by me earlier) since most even just slightly fat men seem to have smaller penises. Due to E2 and low T they should actually still be not that small cause they are in the low normal range (i guess :) ).
The opposite hold true with skinny men.
However E2 does not seem to have control over the age of the downregulation of the AR, which is way after penis growth actually stops on average.
 
 
 
#14
Massive21
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Re: steroids in puberty, penis size,AR-downregulation 2015/05/10 09:59:47 (permalink)
Testosterone has no bearing on how fast or how big the penis grows.

/thread
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Re: steroids in puberty, penis size,AR-downregulation 2015/05/10 14:53:19 (permalink)
sickert
JoshHardcastle
Androgens act as a triggers to various stages of development, but are not in themselves the determinants of size.  This is easily evidenced by the fact that heavy androgen users do not have further development of the penis.  Early initiation of puberty using androgens is a very risky business, as it can advance steps in the development programming when other required steps have not yet complete. 
 
In the case of prenatal exposure, very serious teratological problems can result for similar reasons ie other developmental programs have not completed, however the magnitude of the effect is much greater.  This can result in obvious problems such as urethral openings being in the wrong place (hypospadias), lack of final secondary sex characteristics ( penis, genitals, etc), neurological problems, or serious disorders of other secreting glands eg( adrenals ).
 
Specifically with the OP, exogenous androgens can be used in some cases where sexual development is stunted, only where the cause of the lack of development is due to androgen insufficiency.  Other cases such as androgen insensitivity, PAIS, etc would be unaffected.  This is definitely something which would need to be undertaken under a specialist/consultant.
 
When considering development of various tissues, one needs to consider the regulatory complexity in their development.  The penis is very tightly regulated (as evidenced by the low incidence of penile cancers).  In comparison, skeletal muscle is an extremely plastic tissue (as is adipose), which is easily changed in response to both endocrinal and metabolic factors.
 
One popular misunderstanding amongst steroid users who claim that their penis has grown on steroids, is the effect of the hormonal changes on the vasomotor function.  That is a transient effect and is fully reversed upon cessation.
 
On a more general note, If your penis is working ie you can pee out of it, and get erections, then I would leave it be, if not then see your GP.  Life is too short to get hung up on the size of your knob, and such insecurities will interfere with your enjoyment of sex and life in general.
 
J





Thanks for the reply. Given i posted several times now ,i think i gained my creds and am to be answered.
 
Concerning the regulatory complexity: I agree with you but i do not think that cancer is a valid indicator here since it seems to mainly affect the skin like skin cancer.
It seems logical that skeletal muscle, way less complex, responds more easily to exogenous hormone injection.
I just do not get why a nonexistent massive penis growth of AAS-users over 25 is a sign that seriously raising the level to the top of the physiological level before age 17 would not result in a penis on the 97. percentile (let s say 7 inch), ignoring the definite dangers of seriously messing up your homeostatis and fertility and bone growth. Assuming the variability of the individual genetic makeup is taken into account.
(I am older and therefore do not plan to do it)
 
 
Concerning the studies originally posted by me:  The androgen receptor downregulation does not seem to coincide with the cessation of penis growth. Does the term down-regulation refer to the number of the receptors or does that also involve changed sensitivity.
 
I thought that guys in this forum know the gossip: There must be some teenagers who actually take steroids aged 15 (though it seems like risky business) ? So have you heard any stories or know exact cases?
 
I am doubting the thesis of the predetermined size (posted by me earlier) since most even just slightly fat men seem to have smaller penises. Due to E2 and low T they should actually still be not that small cause they are in the low normal range (i guess :) ).
The opposite hold true with skinny men.
However E2 does not seem to have control over the age of the downregulation of the AR, which is way after penis growth actually stops on average.
 
 
 


I was skinny as a kid and right up until my mid/late twenties. My penis was and still is life destroyingly small. Your theory doesnt make sense.
#16
sickert
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Re: steroids in puberty, penis size,AR-downregulation 2015/05/10 15:15:24 (permalink)
Massive21
Testosterone has no bearing on how fast or how big the penis grows.

/thread



Hi . That is definetely untrue as John has pointed out above. It makes sense that there is some genetic limit and i guess that this point is proven.
It comes down to the intraindividual variance in size. Would a man predetermined for ,lets say, 18 cm penis only reach 16 cm,  when he goes through puberty on the "low normal level" in contrast to "the higher normal level".
But he would not end up with 11-12 cm, which is the "low normal level".
 
 
post edited by sickert - 2015/05/10 15:19:22
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stevebullmastiff
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Re: steroids in puberty, penis size,AR-downregulation 2015/05/11 23:47:05 (permalink)
Penis size  Is mostly down to genetics if your dad got a small 1 and your mothers dad got a small 1 very gd chance you won't have anything special hanging between your legs.
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sickert
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Re: steroids in puberty, penis size,AR-downregulation 2015/05/12 11:49:14 (permalink)
stevebullmastiff
Penis size  Is mostly down to genetics if your dad got a small 1 and your mothers dad got a small 1 very gd chance you won't have anything special hanging between your legs.



Well, genetics do play a major role. That is illustrated by my texts.
However, i am wondering if one could "optimize" a penis (or say child) by bringing him up to the high normal range as opposed to the low normal range.
It comes down to the question what stops penis growth AND puberty.
The difference in a 7 inch an a 4 inch penis is not going thru puberty on a level of 30 nmol T vs. 7 nmol T?
Cause that thesis is highly supported by the fact that obese men generally have rather small penises
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BigWig
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Re: steroids in puberty, penis size,AR-downregulation 2015/05/12 14:47:48 (permalink)
I still dont understand. Im sure there are blokes of all shapes and sizes with different sized knobs. What facts or data are provided  by "some fat blokes have small d1cks" ?
#20
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